Research Articles
Cross-Species Pharmacokinetics: From Fundamental Principles to Model-Informed Drug Development
This article provides a comprehensive examination of comparative pharmacokinetics across species, a critical discipline for translational medicine and drug development.
Defining the Taxonomic Domain of Applicability in Adverse Outcome Pathways: A Framework for Cross-Species Prediction in Toxicology and Drug Development
This article provides a comprehensive overview of the Taxonomic Domain of Applicability (tDOA) for Adverse Outcome Pathways (AOPs), a critical concept for enhancing the reliability of cross-species extrapolation in chemical...
Validating New Approach Methodologies (NAMs): A 2025 Roadmap for Scientific Confidence and Regulatory Acceptance
This article provides a comprehensive guide for researchers and drug development professionals on validating New Approach Methodologies (NAMs) for regulatory decision-making.
Laboratory vs Field Ecotoxicology: Bridging the Gap in Effect Endpoints for Chemical Safety Assessment
This article provides a comprehensive analysis for researchers and drug development professionals on the critical comparison between laboratory and field ecotoxicological effect endpoints.
Bridging the Data Gap: Advanced Strategies for Robust Chemical Assessments in Drug Development
This article provides a comprehensive guide for researchers and drug development professionals on identifying, addressing, and validating data gaps in chemical hazard and risk assessment.
From Lab to Reality: A Comprehensive Guide to Laboratory-to-Field Extrapolation Methods
This article provides researchers, scientists, and drug development professionals with a detailed exploration of laboratory-to-field extrapolation methodologies.
Modern Strategies for Chemical Mixture Risk Assessment: From Foundational Concepts to Advanced Applications
This comprehensive review addresses the critical challenge of assessing health risks from chemical mixtures, moving beyond traditional single-chemical evaluation paradigms.
A Comprehensive Guide to Control Performance Test Reporting for Robust Biomedical Research
This article provides a comprehensive framework for control performance test reporting, tailored for researchers, scientists, and professionals in drug development.
Beyond the Dose: Mastering Experimental Design in Ecotoxicology by Controlling Confounding Factors
This article provides a comprehensive framework for researchers, scientists, and drug development professionals to identify, manage, and mitigate confounding factors in ecotoxicology experimental design.
Raw Data Archiving in Ecotoxicology: Enhancing Reproducibility, Regulatory Compliance, and Sustainable Research
This article addresses the critical role of raw data archiving in ecotoxicology for researchers, scientists, and drug development professionals.