Research Articles
High-Throughput In Vitro Assays for Ecological Species: A New Paradigm in Ecotoxicology and Drug Development
This article explores the transformative role of high-throughput in vitro assays in assessing chemical effects across diverse ecological species.
Species Sensitivity Distributions Comparison: From Ecological Risk Assessment to Pharmaceutical Safety
This comprehensive review explores species sensitivity distributions (SSDs) as critical tools for understanding interspecies variability in chemical sensitivity.
Bioavailability in Toxicity Testing: Bridging Exposure and Biological Effect for Accurate Risk Assessment
This article provides a comprehensive overview of the critical role bioavailability plays in modern toxicity testing.
Read-Across in Chemical Safety: A Modern Framework for Data Gap Filling and Regulatory Acceptance
This article provides a comprehensive overview of read-across approaches for chemical safety assessment, exploring their foundational principles, methodological applications, and optimization strategies.
Protein Sequence Similarity and Susceptibility Prediction: From Foundations to Clinical Applications
Predicting molecular susceptibility from protein sequences is a cornerstone of modern bioinformatics, crucial for understanding genetic diseases and accelerating drug discovery.
QSAR Validation: Best Practices, Modern Methods, and Regulatory Compliance for Predictive Modeling
This article provides a comprehensive guide to Quantitative Structure-Activity Relationship (QSAR) model validation, a critical pillar of computational drug discovery and chemical safety assessment.
Cross-Species Extrapolation of PPCP Targets: Bridging Preclinical Models to Human Therapeutics
This article provides a comprehensive overview of modern strategies for cross-species extrapolation of Pharmaceuticals and Personal Care Products (PPCP) targets, a critical process in drug discovery and toxicology.
Cross-Species Pharmacokinetics: From Fundamental Principles to Model-Informed Drug Development
This article provides a comprehensive examination of comparative pharmacokinetics across species, a critical discipline for translational medicine and drug development.
Defining the Taxonomic Domain of Applicability in Adverse Outcome Pathways: A Framework for Cross-Species Prediction in Toxicology and Drug Development
This article provides a comprehensive overview of the Taxonomic Domain of Applicability (tDOA) for Adverse Outcome Pathways (AOPs), a critical concept for enhancing the reliability of cross-species extrapolation in chemical...
Validating New Approach Methodologies (NAMs): A 2025 Roadmap for Scientific Confidence and Regulatory Acceptance
This article provides a comprehensive guide for researchers and drug development professionals on validating New Approach Methodologies (NAMs) for regulatory decision-making.